Everyone’s talking about the hand Rejuran Healer, and for good reason: It is a wondrous procedure for healing skin from within and anti-inflammatory effects, as it naturally regenerates damaged tissues to create healthier skin and improve skin elasticity.
PDRN (Polynucleotide)
The active ingredient of PDRN (polynucleotide) is DNA fragments optimised when administrated into the body through a series of mini-injections. Rejuran Healer also promotes an anti-inflammatory effect and is HSA-approved as PDRN naturally exists in the body. It not only improves skin texture, but also has wound healing properties.
However, just like any other procedure, Rejuran is not quite a one-stop cure-all.
Read on as we dispel the top myths about this miracle skin healing treatment called Rejuran.
REJURAN does not replace fillers
The Rejuran Healer repairs and helps reduce damaged skin cells using salmon DNA, biologically increasing the metabolic activity of cells in the skin. In layman terms, it helps stimulate cells in the body to regenerate by “awakening” old cells to get them to work again. This is drastically different from fillers, which compose of naturally derived synthetic materials and it works by plumping the injected area until the wrinkle or fold is gone without a biological process of cell stimulation.
REJURAN is not a skin booster
A skin booster is also a type of dermal filler used to improve the skin’s quality by drawing water to the skin to keep it hydrated and plump, hence increasing its smoothness, elasticity and firmness. This is different from the Rejuran Healer as the latter helps reverse ageing by repairing skin at a cellular level and reduce uneven skin or acne scars through stimulation of growth factors and increased microcirculation. Therefore, it is a skin rejuvenator that reduces the signs of age.
REJURAN is not just for mature skin
Rejuran Healer has multiple benefits, from reducing wrinkles through skin regeneration, to boosting moisture levels for radiant looking skin. However, that doesn’t mean that it is a strictly anti-ageing treatment for mature skin. Rejuran has shown to be highly effective at reducing the appearance of acne scars, for example, and can be part of a skin resurfacing treatment plan alongside laser treatments.
REJURAN injections are not painless
Despite the use of a numbing cream, it does sting; not to mention, it leaves the skin bumpy and red immediately after treatment. However, it is minimally invasive and the side effects will go down shortly after. For many, the benefits of Rejuran Healer far outweigh the discomfort; plus, the session is over in just 10 minutes.
Patient receiving a REJURAN treatment
REJURAN For Acne Scars
The Rejuran Healer may not be an all-encompassing treatment for everyone, but its benefits are endless. It is also highly effective for acne scars. Read on to learn more about how this miracle healer can help you regain radiant, smooth skin.
How Does Rejuran Healer Actually Work?
Rejuran Healer contains polynucleotides (PDRN) derived from salmon DNA. When injected into the dermis, these chains of nucleotides are absorbed by skin cells and used as building blocks to repair and regenerate damaged tissue. The polynucleotides stimulate fibroblasts — the cells responsible for producing collagen and elastin — leading to improved skin texture, elasticity, and hydration over time.
Unlike hyaluronic acid fillers, which work primarily by adding volume, or skin boosters like Juvederm Volite, which hydrate from within, Rejuran works at a cellular level. It triggers a biological repair response rather than simply filling or hydrating. This is why results tend to build gradually over several weeks and are more durable than many superficial treatments.
The treatment is typically delivered through a series of microinjections across the face. A fine needle or cannula is used to deposit small blebs of Rejuran just under the skin surface. Topical anaesthetic cream is applied beforehand to reduce discomfort. The entire procedure takes around 30 to 45 minutes, and most patients can return to daily activities the same day, with minor redness or swelling that settles within 24 to 48 hours.
Who Is an Ideal Candidate for Rejuran?
Rejuran Healer suits a wide range of patients. It is particularly effective for those experiencing early signs of skin ageing — fine lines, loss of elasticity, dullness, and uneven skin tone. It is also an excellent option for patients with acne-scarred skin, as the regenerative effect of PDRN helps to soften shallow scars and improve overall skin quality.
Patients in their late twenties and thirties often use Rejuran as a preventive treatment to maintain skin quality before significant volume loss or deep wrinkles develop. Those in their forties and beyond may use it in combination with fillers or energy-based devices to achieve more comprehensive rejuvenation. It is generally not recommended during pregnancy or breastfeeding.
People with a known allergy to salmon or fish products should inform their doctor before the procedure. While allergic reactions to PDRN are rare, they are possible. A patch test or allergy history review is advisable in such cases.
What Results Can You Realistically Expect?
Results from Rejuran Healer are gradual and cumulative. Most patients notice initial improvements in skin hydration and a subtle glow within two to three weeks of the first session. Skin texture improvements and firming become more apparent after the second or third session. A standard course consists of three sessions spaced four weeks apart, followed by maintenance sessions every three to six months.
Unlike dramatic procedures such as laser resurfacing or deep chemical peels, Rejuran delivers subtle, natural-looking improvements. The goal is healthier, more resilient skin — not a dramatic transformation. Patients who expect immediate and dramatic results from a single session may be disappointed. Those who commit to a proper course and maintenance schedule are typically very satisfied with the long-term outcome.
Combining Rejuran with Other Treatments
Rejuran Healer works well as part of a combination treatment plan. It is commonly combined with laser treatments — such as Pico laser or CO2 fractional laser — to simultaneously address pigmentation and resurface the skin while the Rejuran stimulates repair and healing. Many clinics in Singapore offer combination protocols precisely because the treatments are synergistic.
It can also be layered with botulinum toxin (Botox) to address dynamic wrinkles while Rejuran improves overall skin quality. Combining it with hyaluronic acid fillers allows clinics to restore volume and improve skin health in the same session. However, not all combinations are appropriate for every patient, and your doctor should advise on the best protocol based on your skin concerns and goals.
Frequently Asked Questions About Rejuran Healer
How long do Rejuran results last?
Results from a standard course of three sessions typically last six to twelve months before a maintenance session is recommended. Individual results vary based on skin condition, age, lifestyle factors such as sun exposure and smoking, and skincare routine. Consistent maintenance sessions help sustain the improvements over the long term.
Is Rejuran the same as PDRN therapy?
Rejuran is a brand of PDRN (polynucleotide) treatment. There are several other PDRN-based products on the market, including Rejuran S (formulated specifically for acne scars) and Rejuran I (for under-eye treatment). The core active ingredient — salmon-derived polynucleotides — is the same, but formulations, molecular weight, and concentration may differ between brands and variants.
How does Rejuran compare to Profhilo?
Both Rejuran and Profhilo are injectable treatments designed to improve skin quality rather than add volume. Profhilo uses high and low molecular weight hyaluronic acid to remodel skin and stimulate collagen. Rejuran uses polynucleotides to repair skin at a cellular level. They work through different mechanisms and can be complementary. Your doctor can advise which is more appropriate for your skin concerns, or whether combining both is beneficial.
Is Rejuran safe for Asian skin?
Yes. Rejuran Healer was developed in South Korea and has been extensively used across East and Southeast Asia, where it has a strong safety record. It is well-suited to Asian skin types and skin tones. There is no increased risk of post-inflammatory hyperpigmentation from the injections themselves, making it a suitable option for those with Fitzpatrick skin types III to V who need to avoid treatments that may trigger pigmentation.
What to Do Before and After Your Rejuran Session
Preparing properly for a Rejuran treatment helps minimise bruising and maximise results. In the week before your session, avoid blood-thinning medications and supplements such as aspirin, ibuprofen, fish oil, vitamin E, and ginkgo biloba, as these increase the risk of bruising at injection sites. Avoid alcohol for 24 hours before the appointment. Come to the clinic with clean skin, free of makeup or skincare products.
After the treatment, expect small bumps or wheals at the injection sites — these are normal and settle within a few hours to a day. Avoid touching or pressing on the treated areas. Skip heavy exercise, saunas, and swimming pools for 24 to 48 hours. Apply sunscreen diligently, as the skin is more sensitive to UV immediately after treatment. Most patients find they can resume their normal skincare routine within 24 hours.
To enhance and prolong your results, use a gentle, hydrating skincare routine with ingredients such as hyaluronic acid, niacinamide, and antioxidants. Consistent daily sunscreen application is the single most important habit to protect your investment in skin regeneration treatments. Staying well hydrated, eating a diet rich in antioxidants, and avoiding smoking also contribute to better and longer-lasting skin quality outcomes.
Can Rejuran be done on the body as well as the face?
Yes. While Rejuran is most commonly associated with facial skin rejuvenation, it can also be used on the neck, décolletage, and hands — areas that often show signs of ageing before the face receives attention. Rejuran S, a higher-viscosity formulation, is used specifically for acne scar treatment and may be applied across the face where scars are present. Consult your doctor about the appropriate formulation and technique for the area you wish to treat.
How many sessions of Rejuran do I need to see results?
Most patients undergo an initial course of three sessions spaced four weeks apart. Visible improvements in skin texture and hydration typically appear after the first or second session, with the most significant results evident four to six weeks after completing the full course. For mild skin concerns, some patients opt for a single session as a top-up, though a full course delivers substantially better outcomes. After the initial course, maintenance sessions every three to six months are recommended to sustain the benefits.
Choosing a Clinic for Rejuran in Singapore
Singapore has a large number of aesthetic clinics offering Rejuran Healer treatments, ranging from GP-run aesthetic clinics to specialist dermatology and plastic surgery practices. When choosing a clinic, prioritise doctors who are registered with the Singapore Medical Council and have experience specifically with injectable treatments. A consultation before the procedure — where the doctor assesses your skin, discusses your goals, and sets realistic expectations — is a positive sign of a responsible practice.
Be cautious of clinics offering significantly below-market prices. Authentic Rejuran Healer uses CE-marked polynucleotide products and requires trained administration to achieve safe and consistent results. Prices in Singapore typically range from S$600 to S$1,200 per session depending on the clinic, the number of vials used, and whether additional treatments are combined. A full course of three sessions commonly costs between S$1,500 and S$3,000.
Reading verified patient reviews on platforms such as Google Maps, RealSelf, or the Singapore Medical Council’s directory can help you gauge a clinic’s track record. Before committing, ask to see before-and-after photos of actual patients treated at that clinic — not stock images — and ask the doctor about the specific protocol and product they use.
Ultimately, the best Rejuran results come from a combination of a skilled, experienced injector, an appropriate treatment protocol tailored to your skin, and a consistent skincare and sun-protection routine at home. Rejuran Healer is a scientifically grounded treatment with a strong evidence base — when administered correctly, it reliably delivers meaningful improvements in skin health and quality over time.
Where to find Rejuran Healer treatment in Singapore
Doctor’s name?
Dr Ong
Where I did it?
Illumia Medical
501 Orchard Road #05-12 Wheelock Place Singapore 238880
Tel: 6464 6454
clinic@illumiamedical.com
Price?
Rejuran Healer Injection – $750
